Friday, January 24, 2020

Change and Continuity in the Guilded Age Essay -- essays research pape

Change and Continuity in the Gilded Age Emergence of Modern America   Ã‚  Ã‚  Ã‚  Ã‚   â€Å"Every day things change, but basically they stay the same.†-Dave Matthews Change and continuity are two major principles of life. They can easily be applied to history because their application accurately portrays the circumstances, and characterizes the era of interest. Merriam-Webster defines continuity as an uninterrupted connection, succession, or union, or an uninterrupted duration or continuation especially without essential change. Change is defined as to make different in some particular, to alter, to make radically different, to transform, or to give a different position, course, or direction to. These antonyms are critical in understanding history.   Ã‚  Ã‚  Ã‚  Ã‚  The gilded age of the United States is an extremely interesting era that generally gets diluted in the teaching of American history. However, this age was very critical in the development of many modern ideas and institutions we utilize today. Change and continuity are both prevalent in this time, but change is the primary element from 1877 to 1900.   Ã‚  Ã‚  Ã‚  Ã‚  When discussing change in the late 1800’s a few things come to mind, but the progression of capitalism was a major catalyst for most of them. Capitalism is an economic system of free market. It promotes private or corporate ownership of goods from investments based upon price, production, and distribution of goods. This new idea tended to promise wealth and stability, but when the distinction between the working lower class and bourgeoisie became more evident, people were irritated. Capitalism began to exploit the greed in man and bring fear to the strongest of wills. Many dreamed of this as the golden age of man kind and saw new prosperity as a benefit for all â€Å"for how could there be greed when all had enough.†(George, p.21) Poverty spread through the working class like disease and forced millions of Americans to fight for survival. In a trip to Chicago Rudyard Kipling furiously describes the dreary, money driven conditions that consumed the ea rth, water, and air. â€Å"I spent ten hours in that huge wilderness, wandering through scores of miles of these terrible streets, and jostling some few hundred thousand of these terrible people who talked money through their noses.... ...was also continuity. The country still faced severe issues of poverty, racism, and oppression, but the people of America were growing wise and understanding the system and how to change it. Inventions, technology and industrialization were fueled during this time, constantly changing and improving, to create a better America. Ideologically the United States was spawning great new ideas on government regulations, and equal rights. These forefront dreams created much of American society, as we know it today. It pushed the envelope and made top officials see that if the people were unhappy, the nation would not benefit but struggle to come to consensus. Though the end of this age did not completely put all the standards into practice, it set a foundation for future progress. In my opinion where there is change there is always continuity, and vice versa, but change primarily characterized the gilded age. Bibliography 1.  Ã‚  Ã‚  Ã‚  Ã‚  Fink, Leon. Major Problems in the Gilded Age and Progressive Era: second edition. Houghton Mifflin, 2001. 2.  Ã‚  Ã‚  Ã‚  Ã‚  Merriam-Webster Dictionary. http://www.merriam-webster.com Change and Continuity in the Guilded Age Essay -- essays research pape Change and Continuity in the Gilded Age Emergence of Modern America   Ã‚  Ã‚  Ã‚  Ã‚   â€Å"Every day things change, but basically they stay the same.†-Dave Matthews Change and continuity are two major principles of life. They can easily be applied to history because their application accurately portrays the circumstances, and characterizes the era of interest. Merriam-Webster defines continuity as an uninterrupted connection, succession, or union, or an uninterrupted duration or continuation especially without essential change. Change is defined as to make different in some particular, to alter, to make radically different, to transform, or to give a different position, course, or direction to. These antonyms are critical in understanding history.   Ã‚  Ã‚  Ã‚  Ã‚  The gilded age of the United States is an extremely interesting era that generally gets diluted in the teaching of American history. However, this age was very critical in the development of many modern ideas and institutions we utilize today. Change and continuity are both prevalent in this time, but change is the primary element from 1877 to 1900.   Ã‚  Ã‚  Ã‚  Ã‚  When discussing change in the late 1800’s a few things come to mind, but the progression of capitalism was a major catalyst for most of them. Capitalism is an economic system of free market. It promotes private or corporate ownership of goods from investments based upon price, production, and distribution of goods. This new idea tended to promise wealth and stability, but when the distinction between the working lower class and bourgeoisie became more evident, people were irritated. Capitalism began to exploit the greed in man and bring fear to the strongest of wills. Many dreamed of this as the golden age of man kind and saw new prosperity as a benefit for all â€Å"for how could there be greed when all had enough.†(George, p.21) Poverty spread through the working class like disease and forced millions of Americans to fight for survival. In a trip to Chicago Rudyard Kipling furiously describes the dreary, money driven conditions that consumed the ea rth, water, and air. â€Å"I spent ten hours in that huge wilderness, wandering through scores of miles of these terrible streets, and jostling some few hundred thousand of these terrible people who talked money through their noses.... ...was also continuity. The country still faced severe issues of poverty, racism, and oppression, but the people of America were growing wise and understanding the system and how to change it. Inventions, technology and industrialization were fueled during this time, constantly changing and improving, to create a better America. Ideologically the United States was spawning great new ideas on government regulations, and equal rights. These forefront dreams created much of American society, as we know it today. It pushed the envelope and made top officials see that if the people were unhappy, the nation would not benefit but struggle to come to consensus. Though the end of this age did not completely put all the standards into practice, it set a foundation for future progress. In my opinion where there is change there is always continuity, and vice versa, but change primarily characterized the gilded age. Bibliography 1.  Ã‚  Ã‚  Ã‚  Ã‚  Fink, Leon. Major Problems in the Gilded Age and Progressive Era: second edition. Houghton Mifflin, 2001. 2.  Ã‚  Ã‚  Ã‚  Ã‚  Merriam-Webster Dictionary. http://www.merriam-webster.com

Thursday, January 16, 2020

Blood Clotting Essay

Blood clotting is an adaptive/defensive mechanism of the human body. Its primary purpose is to prevent the loss of blood from the cardiovascular system from damaged blood vessels in order to avoid shock and possible death. This accomplished by a process called coagulation wherein blood solidify at the site of injury through a complex process involving platelet aggregation and fibrin formation coupled with thrombin and a dozen other clotting factors. Though the mechanism is designed to prevent deleterious harm, clotting can also be harmful especially when inappropriately triggered such as in the case of strokes and infarctions. In the article by Cathleen Genova, she discusses the findings of a report made in the April 17th 2009 issue of Cell, a journal from Cell Press Publication, where researchers found a possible way of preventing life-threatening clots. The discovery might offer a new way to fight clot formation before it can even begin, according to the researchers. According to the findings, thrombin isn’t the only player in the clotting process, in fact â€Å"enzymes known as matrix metalloproteases have recently emerged as important players in platelet function and the biology of blood vessels. Two of those enzymes, MMP-1 and MMP-2 can actually encourage platelet activation† early in the clotting process. If treatments were aimed at blocking the MMP1-PAR1 pathway, a new way of treating patients with acute coronary syndromes may be developed. The advantages of such treatments, the researchers predict, would be that â€Å"an MMP-1 inhibitor might be better tolerated† especially since careful balance between the risk of dangerous blood clots and the risk of bleeding must be kept in mind. Works Cited Genova, Cathleen. â€Å"How Life-Threatening Blood Clots Take Hold. † Medical News Today. MediLexicon, Intrnational Ltd. Accessed 23 April 2009 ARTICLE http://www. medicalnewstoday. com/articles/146508. php How Life-Threatening Blood Clots Take Hold Article Date: 18 Apr 2009 – 0:00 PDT When plaques coating blood vessel walls rupture and expose collagen, platelets spring into action to form a blood clot at the damaged site. Now, a new report in the April 17th issue of the journal Cell, a Cell Press publication, reveals how those life-threatening clots – a leading cause of death in the United States, Europe and other industrialized countries – get an early grip. The discovery might offer a new way to fight clot formation before it can even begin, according to the researchers. â€Å"Compared to other diseases, blood clotting has been very well understood,† said Athan Kuliopulos of Tufts Medical Center and Tufts University School of Medicine. Nevertheless, he continued, many people still suffer from heart attacks, ischemic stroke and death as a result of clot formation. â€Å"Drugs designed to inhibit clots through known pathways are widely used by millions. They work well, but not perfectly. There is still an unmet need. † Those drugs include aspirin and the so-called thienopyridines, including Clopidogrel (trade name Plavix). Scientists have known that a protein called thrombin plays an important role in clot formation as a potent activator of platelets. It also cuts fibrinogen into fibrin, a fibrous protein that works together with platelets to form a clot. But thrombin isn’t the whole story. Enzymes known as matrix metalloproteases have recently emerged as important players in platelet function and the biology of blood vessels. Two of those enzymes, MMP-1 and MMP-2 can actually encourage platelet activation, according to earlier studies, although the means were unknown. In cancer cells too, MMP-1 activates a receptor known as PAR1 – the same receptor that is also responsible for receiving the thrombin signal on human platelets. â€Å"There is abundant proMMP-1 coating platelets,† Kuliopulos said. â€Å"We thought maybe it was on the outside waiting to be activated by something. Maybe it could be involved in an early event in blood clotting, before thrombin is around. † Indeed, Kuliopulos’ team has now connected those dots. They show that exposure of platelets to collagen activates MMP-1, which in turn directly cut PAR1 on the surface of platelets. Collagen is the first thing a platelet â€Å"sees† when a blood vessel ruptures or is cut. The MMP-1-PAR1 pathway activates another set of molecular players known to be involved in early clot formation, he said. Those activated platelets change their shape, sending out spikes and membrane sheets. â€Å"Within seconds, they become more sticky,† adhering to the vessel surface and then other platelets. Moreover, they show that treatments that block the MMP1-PAR1 pathway prevent blood clots from forming in the presence of collagen, suggesting that drugs targeting this metalloprotease-receptor system could offer a new way to treat patients with acute coronary syndromes. According to the new results, PAR1 inhibitors already being tested in clinical trials might have an added benefit, Kuliopulos said. It’s also possible they might work a little too well, since there is a careful balance between the risk of dangerous blood clots and the risk of bleeding. â€Å"An MMP-1 inhibitor might be better tolerated,† he said. The researchers include Vishal Trivedi, Adrienne Boire, Boris Tchernychev, Nicole C. Kaneider, Andrew J. Leger, Katie O’Callaghan, Lidija Covic, and Athan Kuliopulos, of Tufts University School of Medicine, Molecular Oncology Research Institute, Tufts Medical Center, Boston, MA. Source: Cathleen Genova Cell Press

Tuesday, January 7, 2020

The Main Categories of Market Structures Essay - 1668 Words

The Main Categories of Market Structures Recent industry analyses typically have strong relation with economic theories. There is a theory, belongs to microeconomics, divides industries into categories according t the degree of competition that exists between the firms within the industry, i.e. the theory of Alternative Market Structures. This essay based on three questions divides into 3 parts to explain and evaluate the questions. This essay (PART A) outlines the main categories of market structures, and shows the theoretical features of two of them, i.e. Perfect Competition and Oligopoly. This essay (PART B) evaluates upon the most relevant structure in regard to the UK supermarket industry. This essay (PART C)†¦show more content†¦There is a freedom of entry into and exit from the industry firms. There are no significant financial, legal, technological or other barriers to new firms entering the industry or existing firms leaving it. 3. All firms in the industry sell identical/homogenous product. It makes perfect competition so extremely competitive and so rare. The important thing is that the product of a firm is considered by the buyers to be the same as that of any other firm. This ensures that no buyer has any economic incentive to pay any firm higher price for the product than is charged by other firms. 4. Each firm is a price taker and has no influence on the market price. They are unable to affect the prices by changing the amount of product that is offers for sale (Fig 1). This is because the output is such a small portion of total industry supply that has nearly no effect on market supply. Therefore the firm has to be a price taker; otherwise, it will reduce profit. In the real world the perfect competition is rare. The model of perfect competition serves usually as a benchmark of economic efficiency against which real world markets can be measured. Nevertheless, it is still beneficial to study it as a model. Market power refers to the ability to influence price of a product. In a perfectly competitive market, there is little market power for producers. In contrast, Oligopoly refers to a market where a few large firms sell a product that may be alike orShow MoreRelatedProcter Gambler: Organisation1063 Words   |  5 PagesCase: Procter Gamble: Organization 2005       1.Why did the US organizational structure shift from product grouping in the 1950s to a matrix in the 1980s? Why did the European organizational structure shift from geographic grouping in the 1950s to category management in the 1980s? 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